%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Syed Abbas Bukhari, Michael C. Saul, Christopher H. Seward, Huimin Zhang, Miles Bensky, Noelle James, Sihai Dave Zhao, Sriram Chandrasekaran, Lisa Stubbs, Alison M. Bell
Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks
www.plosgenetics.org
www.plosgenetics.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref001)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref002)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref007)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref008)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref010)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref011)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref013)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref014)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref015)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref016)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref017)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref018)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref019)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref020)>>
endobj
29 0 obj
<>/Border[0 0 0]/A 31 0 R>>
endobj
31 0 obj
<>
endobj
30 0 obj
<>/Border[0 0 0]/A 32 0 R>>
endobj
32 0 obj
<>
endobj
14 0 obj
[33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R]
endobj
33 0 obj
<>stream
q
0.955 g
0 w
199.9998 713.9999 m
575.9997 713.9999 l
575.9997 501.0004 l
199.9998 501.0004 l
f*
0.83 0.64 0.02 0 k
203.4142 406.9417 m
208.1764 406.9417 l
h
f*
339.4205 393.9024 m
344.1827 393.9024 l
h
f*
349.3984 393.9024 m
354.1039 393.9024 l
h
f*
423.6661 393.9024 m
428.4283 393.9024 l
h
f*
433.6441 393.9024 m
443.1118 393.9024 l
h
f*
552.2457 393.9024 m
561.7701 393.9024 l
h
f*
200.0126 380.9197 m
209.537 380.9197 l
h
f*
519.8173 328.9323 m
529.285 328.9323 l
h
f*
533.7638 328.9323 m
543.2882 328.9323 l
h
f*
285.6756 263.9055 m
295.2 263.9055 l
h
f*
299.6787 263.9055 m
309.2031 263.9055 l
h
f*
501.052 250.9228 m
510.5197 250.9228 l
h
f*
514.9984 250.9228 m
524.5228 250.9228 l
h
f*
550.9984 159.9307 m
560.5228 159.9307 l
h
f*
0 g
1 j
1 J
11.9999 0 0 11.9999 209.9905 696.0188 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Author)Tj
3.137 0 Td
(summary)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 209.9905 677.9905 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Social)Tj
2.5738 0 Td
(interactions)Tj
4.9663 0 Td
(provoke)Tj
3.4979 0 Td
(changes)Tj
3.4072 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(brain)Tj
2.3471 0 Td
(and)Tj
1.7291 0 Td
(behavior)Tj
3.7134 0 Td
(but)Tj
1.5534 0 Td
(their)Tj
2.1033 0 Td
(underlying)Tj
4.6034 0 Td
(molec-)Tj
-33.0007 -1.2982 Td
(ular)Tj
1.8028 0 Td
(mechanisms)Tj
5.2043 0 Td
(remain)Tj
3.0841 0 Td
(obscure.)Tj
3.566 0 Td
(Male)Tj
2.2167 0 Td
(sticklebacks)Tj
4.9549 0 Td
(are)Tj
1.4513 0 Td
(small)Tj
2.3244 0 Td
(fish)Tj
1.6668 0 Td
(whose)Tj
2.7212 0 Td
(fitness)Tj
2.7666 0 Td
(depends)Tj
-31.7591 -1.2983 Td
(on)Tj
1.2755 0 Td
(their)Tj
2.109 0 Td
(ability)Tj
2.6929 0 Td
(to)Tj
1.0261 0 Td
(defend)Tj
2.9594 0 Td
(a)Tj
0.6519 0 Td
(territory.)Tj
3.8098 0 Td
(Here,)Tj
2.4321 0 Td
(by)Tj
1.1792 0 Td
(measuring)Tj
4.439 0 Td
(the)Tj
1.4684 0 Td
(time)Tj
2.0296 0 Td
(course)Tj
2.8346 0 Td
(of)Tj
1.0148 0 Td
(gene)Tj
2.0806 0 Td
(expres-)Tj
-32.0029 -1.3039 Td
(sion)Tj
1.9048 0 Td
(in)Tj
1.0375 0 Td
(response)Tj
3.7304 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(territorial)Tj
4.0762 0 Td
(challenge)Tj
3.9571 0 Td
(in)Tj
1.0375 0 Td
(two)Tj
1.7121 0 Td
(brain)Tj
2.3471 0 Td
(regions,)Tj
3.3902 0 Td
(we)Tj
1.3266 0 Td
(show)Tj
2.296 0 Td
(that)Tj
1.7802 0 Td
(a)Tj
0.6519 0 Td
(single)Tj
2.5342 0 Td
(brief)Tj
-33.4599 -1.2983 Td
(territorial)Tj
4.0761 0 Td
(intrusion)Tj
3.9175 0 Td
(provoked)Tj
4.0252 0 Td
(waves)Tj
2.5738 0 Td
(of)Tj
1.0148 0 Td
(gene)Tj
2.0863 0 Td
(expression)Tj
4.4617 0 Td
(that)Tj
1.7801 0 Td
(persisted)Tj
3.7701 0 Td
(for)Tj
1.3833 0 Td
(hours)Tj
2.5172 0 Td
(after-)Tj
-31.6061 -1.2982 Td
(wards,)Tj
2.8232 0 Td
(with)Tj
2.0013 0 Td
(waves)Tj
2.5738 0 Td
(of)Tj
1.0148 0 Td
(transcription)Tj
5.4368 0 Td
(associated)Tj
4.252 0 Td
(with)Tj
2.0012 0 Td
(distinct)Tj
3.2088 0 Td
(biological)Tj
4.0932 0 Td
(processes.)Tj
4.1896 0 Td
(Moreover,)Tj
-31.5947 -1.3039 Td
(a)Tj
0.6576 0 Td
(single)Tj
2.5285 0 Td
(territorial)Tj
4.0762 0 Td
(challenge)Tj
3.9571 0 Td
(caused)Tj
2.9197 0 Td
(dramatic)Tj
3.7927 0 Td
(changes)Tj
3.4072 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(epigenome.)Tj
4.8359 0 Td
(Changes)Tj
3.6453 0 Td
(in)Tj
1.0375 0 Td
(chro-)Tj
-33.3522 -1.2983 Td
(matin)Tj
2.5851 0 Td
(accessibility)Tj
4.9436 0 Td
(corresponded)Tj
5.726 0 Td
(to)Tj
1.0204 0 Td
(changes)Tj
3.3959 0 Td
(in)Tj
1.0318 0 Td
(gene)Tj
2.075 0 Td
(expression,)Tj
4.6884 0 Td
(and)Tj
1.7235 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.4626 0 Td
(activity)Tj
3.1125 0 Td
(of)Tj
1.0091 0 Td
(tran-)Tj
-33.7944 -1.2983 Td
(scription)Tj
3.7813 0 Td
(factors)Tj
2.9027 0 Td
(operating)Tj
4.0535 0 Td
(within)Tj
2.812 0 Td
(gene)Tj
2.0806 0 Td
(regulatory)Tj
4.32 0 Td
(networks.)Tj
4.1385 0 Td
(This)Tj
1.9843 0 Td
(study)Tj
2.3924 0 Td
(reveals)Tj
2.931 0 Td
(rapid)Tj
2.3357 0 Td
(and)Tj
-33.732 -1.3039 Td
(dramatic)Tj
3.7984 0 Td
(epigenomic)Tj
4.8812 0 Td
(plasticity)Tj
3.787 0 Td
(in)Tj
1.0375 0 Td
(response)Tj
3.7304 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(brief,)Tj
2.3017 0 Td
(highly)Tj
2.7099 0 Td
(consequential)Tj
5.7373 0 Td
(social)Tj
2.4605 0 Td
(interac-)Tj
-32.122 -1.2983 Td
(tion.)Tj
2.0692 0 Td
(These)Tj
2.5625 0 Td
(results)Tj
2.812 0 Td
(suggest)Tj
3.1237 0 Td
(that)Tj
1.7745 0 Td
(meaningful)Tj
4.7905 0 Td
(social)Tj
2.4605 0 Td
(interactions)Tj
4.9663 0 Td
(\(even)Tj
2.4094 0 Td
(brief)Tj
2.0749 0 Td
(ones\))Tj
2.4038 0 Td
(can)Tj
1.6271 0 Td
(pro-)Tj
-33.0744 -1.2982 Td
(voke)Tj
2.1032 0 Td
(waves)Tj
2.5739 0 Td
(of)Tj
1.0148 0 Td
(transcription)Tj
5.4368 0 Td
(and)Tj
1.7291 0 Td
(changes)Tj
3.4016 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(epigenome)Tj
4.6205 0 Td
(which)Tj
2.6475 0 Td
(lead)Tj
1.8539 0 Td
(to)Tj
1.0204 0 Td
(changes)Tj
3.4073 0 Td
(in)Tj
-32.3034 -1.2983 Td
(neural)Tj
2.7722 0 Td
(functioning,)Tj
5.1364 0 Td
(and)Tj
1.7291 0 Td
(those)Tj
2.3357 0 Td
(changes)Tj
3.4072 0 Td
(are)Tj
1.4457 0 Td
(a)Tj
0.6576 0 Td
(mechanism)Tj
4.8416 0 Td
(by)Tj
1.1792 0 Td
(which)Tj
2.6532 0 Td
(animals)Tj
3.3278 0 Td
(update)Tj
2.9537 0 Td
(their)Tj
-32.4394 -1.3039 Td
(assessment)Tj
4.6147 0 Td
(of)Tj
1.0148 0 Td
(their)Tj
2.1033 0 Td
(social)Tj
2.4605 0 Td
(world.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 463.9748 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 447.0236 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Animals)Tj
3.5773 0 Td
(exhibit)Tj
2.9763 0 Td
(remarkable)Tj
4.7508 0 Td
(behavioral)Tj
4.388 0 Td
(plasticity.)Tj
4.0139 0 Td
(Social)Tj
2.5738 0 Td
(interactions)Tj
4.9663 0 Td
(in)Tj
1.0375 0 Td
(particular)Tj
4.1102 0 Td
(can)Tj
1.6271 0 Td
(provoke)Tj
-34.0212 -1.3039 Td
(moment-to-moment)Tj
8.5605 0 Td
(changes)Tj
3.4016 0 Td
(in)Tj
1.0375 0 Td
(behavior.)Tj
3.9344 0 Td
(These)Tj
2.5682 0 Td
(changes)Tj
3.4015 0 Td
(are)Tj
1.4514 0 Td
(coordinated)Tj
5.0569 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(neural)Tj
2.7723 0 Td
(level,)Tj
-34.6051 -1.2982 Td
(but)Tj
1.5533 0 Td
(social)Tj
2.4548 0 Td
(interactions)Tj
4.972 0 Td
(also)Tj
1.7688 0 Td
(elicit)Tj
2.1429 0 Td
(transcriptional)Tj
6.1115 0 Td
(changes)Tj
3.4072 0 Td
(within)Tj
2.812 0 Td
(the)Tj
1.4683 0 Td
(brains)Tj
2.7099 0 Td
(of)Tj
1.0148 0 Td
(behaving)Tj
3.8494 0 Td
(animals)Tj
-34.2649 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.5987 0 Td
(For)Tj
1.6271 0 Td
(example,)Tj
3.7757 0 Td
(genome-wide)Tj
5.6579 0 Td
(transcription)Tj
5.4368 0 Td
(studies)Tj
2.982 0 Td
(show)Tj
2.3018 0 Td
(that)Tj
1.7801 0 Td
(roughly)Tj
3.3165 0 Td
(~10%)Tj
2.5115 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(genome)Tj
-33.4712 -1.3039 Td
(responds)Tj
3.838 0 Td
(to)Tj
1.0205 0 Td
(a)Tj
0.6576 0 Td
(mating)Tj
3.0501 0 Td
(opportunity)Tj
5.0343 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(],)Tj
2.5965 0 Td
(predation)Tj
4.1159 0 Td
(risk)Tj
1.7121 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(],)Tj
3.0727 0 Td
(or)Tj
1.0999 0 Td
(a)Tj
0.6519 0 Td
(territorial)Tj
4.0762 0 Td
(challenge)Tj
3.9572 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
-34.8829 -1.2983 Td
(13)Tj
0 g
(].)Tj
1.1962 -1.2982 Td
(However,)Tj
4.0818 0 Td
(we)Tj
1.3266 0 Td
(know)Tj
2.4548 0 Td
(little)Tj
2.0013 0 Td
(about)Tj
2.4944 0 Td
(the)Tj
1.4684 0 Td
(temporal)Tj
3.8381 0 Td
(and)Tj
1.7291 0 Td
(spatial)Tj
2.7779 0 Td
(dynamics)Tj
4.0535 0 Td
(of)Tj
1.0148 0 Td
(neurogenomic)Tj
6.0548 0 Td
(plastic-)Tj
-34.4917 -1.304 Td
(ity)Tj
1.2415 0 Td
(in)Tj
1.0318 0 Td
(response)Tj
3.7361 0 Td
(to)Tj
1.0261 0 Td
(social)Tj
2.4548 0 Td
(interactions.)Tj
5.193 0 Td
(It)Tj
0.8617 0 Td
(is)Tj
0.8448 0 Td
(likely)Tj
2.3584 0 Td
(that)Tj
1.7745 0 Td
(there)Tj
2.2677 0 Td
(are)Tj
1.4456 0 Td
(waves)Tj
2.5795 0 Td
(of)Tj
1.0148 0 Td
(transcription)Tj
5.4312 0 Td
(associated)Tj
-33.2615 -1.2982 Td
(with)Tj
1.9955 0 Td
(perceiving)Tj
4.3767 0 Td
(social)Tj
2.4548 0 Td
(information,)Tj
5.3007 0 Td
(responding)Tj
4.7509 0 Td
(to)Tj
1.0261 0 Td
(social)Tj
2.4548 0 Td
(information,)Tj
5.2951 0 Td
(maintaining)Tj
5.1193 0 Td
(a)Tj
0.6463 0 Td
(behavioral)Tj
-33.4202 -1.2983 Td
(response,)Tj
3.9571 0 Td
(recovering)Tj
4.473 0 Td
(from)Tj
2.211 0 Td
(the)Tj
1.4684 0 Td
(social)Tj
2.4548 0 Td
(interaction)Tj
4.6091 0 Td
(and)Tj
1.7291 0 Td
(modifying)Tj
4.3653 0 Td
(future)Tj
2.6589 0 Td
(behavior)Tj
3.7134 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(15)Tj
0 g
(].)Tj
1.7348 0 Td
(Static)Tj
-35.1097 -1.2983 Td
(experiments)Tj
5.1363 0 Td
(that)Tj
1.7801 0 Td
(measure)Tj
3.583 0 Td
(gene)Tj
2.0806 0 Td
(expression)Tj
4.4617 0 Td
(at)Tj
0.9525 0 Td
(a)Tj
0.6576 0 Td
(single)Tj
2.5285 0 Td
(time)Tj
2.0296 0 Td
(point)Tj
2.3584 0 Td
(can)Tj
1.6271 0 Td
(only)Tj
1.9729 0 Td
(catch)Tj
2.33 0 Td
(a)Tj
0.652 0 Td
(glimpse)Tj
3.3222 0 Td
(of)Tj
-35.4725 -1.3039 Td
(what)Tj
2.1656 0 Td
(is)Tj
0.8447 0 Td
(probably)Tj
3.7644 0 Td
(a)Tj
0.652 0 Td
(very)Tj
1.9275 0 Td
(dynamic)Tj
3.6964 0 Td
(and)Tj
1.7291 0 Td
(coordinated)Tj
5.057 0 Td
(process.)Tj
-18.6405 -1.2982 Td
(Studies)Tj
3.101 0 Td
(in)Tj
1.0375 0 Td
(development)Tj
5.4085 0 Td
(have)Tj
2.0636 0 Td
(linked)Tj
2.7269 0 Td
(changes)Tj
3.4072 0 Td
(in)Tj
1.0318 0 Td
(chromatin)Tj
4.4164 0 Td
(accessibility)Tj
4.9549 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(time)Tj
2.0296 0 Td
(course)Tj
-34.8432 -1.2983 Td
(of)Tj
1.0147 0 Td
(changes)Tj
3.4016 0 Td
(in)Tj
1.0375 0 Td
(gene)Tj
2.0806 0 Td
(expression)Tj
4.4617 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(activity)Tj
3.1181 0 Td
(of)Tj
1.0148 0 Td
(transcription)Tj
5.4312 0 Td
(factors)Tj
2.9026 0 Td
(operating)Tj
4.0535 0 Td
(within)Tj
2.812 0 Td
(gene)Tj
-34.5314 -1.3039 Td
(regulatory)Tj
4.3199 0 Td
(networks)Tj
3.9061 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(17)Tj
0 g
(].)Tj
1.7348 0 Td
(This)Tj
1.9899 0 Td
(tactic)Tj
2.3641 0 Td
(has)Tj
1.542 0 Td
(also)Tj
1.7688 0 Td
(proven)Tj
3.0387 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(successful)Tj
4.1613 0 Td
(for)Tj
1.3889 0 Td
(examining)Tj
4.4561 0 Td
(acute,)Tj
-34.5881 -1.2983 Td
(short-term)Tj
4.5467 0 Td
(responses)Tj
4.0932 0 Td
(of)Tj
1.0148 0 Td
(other)Tj
2.3471 0 Td
(types,)Tj
2.5001 0 Td
(for)Tj
1.389 0 Td
(example,)Tj
3.7757 0 Td
(in)Tj
1.0318 0 Td
(response)Tj
3.736 0 Td
(to)Tj
1.0262 0 Td
(pathogens)Tj
4.3029 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(19)Tj
0 g
(].)Tj
1.7348 0 Td
(However,)Tj
-33.2331 -1.2982 Td
(whether)Tj
3.4752 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(principles)Tj
4.1669 0 Td
(apply)Tj
2.3868 0 Td
(to)Tj
1.0261 0 Td
(behavioral)Tj
4.3937 0 Td
(stimuli,)Tj
3.2314 0 Td
(and)Tj
1.7292 0 Td
(social)Tj
2.4604 0 Td
(interactions)Tj
4.9663 0 Td
(in)Tj
1.0375 0 Td
(particular,)Tj
4.337 0 Td
(is)Tj
-36.9352 -1.304 Td
(unknown.)Tj
1.1962 -1.2982 Td
(Here,)Tj
2.4321 0 Td
(we)Tj
1.3266 0 Td
(test)Tj
1.6044 0 Td
(the)Tj
1.4683 0 Td
(hypothesis)Tj
4.4674 0 Td
(that)Tj
1.7745 0 Td
(a)Tj
0.6576 0 Td
(brief)Tj
2.0749 0 Td
(social)Tj
2.4605 0 Td
(interaction,)Tj
4.8302 0 Td
(albeit)Tj
2.3981 0 Td
(one)Tj
1.7008 0 Td
(with)Tj
1.9956 0 Td
(strong)Tj
2.7722 0 Td
(implica-)Tj
-33.1594 -1.2983 Td
(tions)Tj
2.1996 0 Td
(for)Tj
1.389 0 Td
(fitness,)Tj
2.9934 0 Td
(is)Tj
0.8447 0 Td
(sufficient)Tj
3.9118 0 Td
(to)Tj
1.0261 0 Td
(induce)Tj
2.9367 0 Td
(transcriptomic)Tj
6.1284 0 Td
(and)Tj
1.7348 0 Td
(epigenomic)Tj
4.8813 0 Td
(responses)Tj
4.0932 0 Td
(that)Tj
1.7801 0 Td
(change)Tj
-33.9191 -1.3039 Td
(over)Tj
1.9729 0 Td
(time.)Tj
2.2563 0 Td
(We)Tj
1.6101 0 Td
(test)Tj
1.5987 0 Td
(this)Tj
1.6781 0 Td
(hypothesis)Tj
4.4617 0 Td
(in)Tj
1.0375 0 Td
(threespined)Tj
4.9096 0 Td
(sticklebacks)Tj
4.9549 0 Td
(\()Tj
/F11 1 Tf
[()-4()9()11()2()20()7()9()11()2()-4()]TJ
5.4482 0 Td
[()6( )1()4(\n)4()7()22()7()-4()]TJ
/F7 1 Tf
(\),)Tj
4.439 0 Td
(a)Tj
0.6519 0 Td
(spe-)Tj
-35.0189 -1.2983 Td
(cies)Tj
1.6951 0 Td
(for)Tj
1.3833 0 Td
(which)Tj
2.6532 0 Td
(successful)Tj
4.1612 0 Td
(territorial)Tj
4.0762 0 Td
(defense)Tj
3.2145 0 Td
(is)Tj
0.8504 0 Td
(critical)Tj
2.948 0 Td
(for)Tj
1.3889 0 Td
(Darwinian)Tj
4.5071 0 Td
(fitness.)Tj
2.9934 0 Td
(Sticklebacks)Tj
5.0739 0 Td
(are)Tj
-34.9452 -1.2982 Td
(small)Tj
2.3243 0 Td
(fish)Tj
1.6668 0 Td
(whose)Tj
2.7212 0 Td
(behavioral)Tj
4.3937 0 Td
(repertoire)Tj
4.1953 0 Td
(has)Tj
1.542 0 Td
(attracted)Tj
3.7247 0 Td
(attention)Tj
3.8438 0 Td
(since)Tj
2.245 0 Td
(the)Tj
1.4683 0 Td
(early)Tj
2.1543 0 Td
(ethologists)Tj
4.4788 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
-34.7582 -1.2983 Td
(Freshwater)Tj
4.6431 0 Td
(sticklebacks)Tj
4.9549 0 Td
(must)Tj
2.228 0 Td
(quickly)Tj
3.1408 0 Td
(establish)Tj
3.6453 0 Td
(territories)Tj
4.1839 0 Td
(because)Tj
3.3165 0 Td
(they)Tj
1.9276 0 Td
(have)Tj
2.0579 0 Td
(a)Tj
0.652 0 Td
(short)Tj
2.2847 0 Td
(window)Tj
3.4412 0 Td
(of)Tj
-36.4759 -1.3039 Td
(opportunity)Tj
5.0342 0 Td
(to)Tj
1.0262 0 Td
(breed)Tj
2.4718 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(spring,)Tj
2.9763 0 Td
(and)Tj
1.7292 0 Td
(die)Tj
1.44 0 Td
(at)Tj
0.9467 0 Td
(the)Tj
1.474 0 Td
(end)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(breeding)Tj
3.753 0 Td
(season.)Tj
3.0841 0 Td
(Male)Tj
2.2167 0 Td
(sticklebacks)Tj
-32.859 -1.2983 Td
(typically)Tj
3.5602 0 Td
(occur)Tj
2.4718 0 Td
(in)Tj
1.0375 0 Td
(neighborhoods)Tj
6.2702 0 Td
(and)Tj
1.7291 0 Td
(function)Tj
3.6284 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6576 0 Td
(dynamic)Tj
3.6963 0 Td
(social)Tj
2.4548 0 Td
(environment)Tj
5.4312 0 Td
(where)Tj
2.6532 0 Td
(they)Tj
-34.6221 -1.2983 Td
(vigorously)Tj
4.3709 0 Td
(defend)Tj
2.9537 0 Td
(individual)Tj
4.2746 0 Td
(nesting)Tj
3.1238 0 Td
(territories)Tj
4.1726 0 Td
(against)Tj
3.0217 0 Td
(intrusions)Tj
4.2689 0 Td
(by)Tj
1.1679 0 Td
(rival)Tj
1.9842 0 Td
(males)Tj
2.5002 0 Td
(and)Tj
1.7178 0 Td
(predators.)Tj
-33.5563 -1.3039 Td
(The)Tj
1.7801 0 Td
(territory)Tj
3.583 0 Td
(is)Tj
0.8504 0 Td
(the)Tj
1.4683 0 Td
(hub)Tj
1.7801 0 Td
(of)Tj
1.0148 0 Td
(family)Tj
2.7326 0 Td
(life,)Tj
1.6668 0 Td
(where)Tj
2.6532 0 Td
(the)Tj
1.4683 0 Td
(father)Tj
2.5625 0 Td
(constructs)Tj
4.3427 0 Td
(a)Tj
0.6519 0 Td
(nest,)Tj
2.075 0 Td
(attracts)Tj
3.1408 0 Td
(females)Tj
3.2144 0 Td
(to)Tj
-34.9849 -1.2982 Td
(mate)Tj
2.194 0 Td
(and)Tj
1.7291 0 Td
(where)Tj
2.6532 0 Td
(he)Tj
1.1679 0 Td
(rears)Tj
2.1826 0 Td
(the)Tj
1.4684 0 Td
(offspring)Tj
3.8324 0 Td
(without)Tj
3.3335 0 Td
(any)Tj
1.6554 0 Td
(help)Tj
1.9332 0 Td
(from)Tj
2.211 0 Td
(the)Tj
1.4684 0 Td
(mother.)Tj
3.3902 0 Td
(If)Tj
0.8504 0 Td
(a)Tj
0.6519 0 Td
(male)Tj
2.143 0 Td
(fails)Tj
1.8199 0 Td
(to)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 133.6819 23.6976 re
W* n
q
133.6252 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 452.4094 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Neurogeno)Tj
4.8543 0 Td
(mics)Tj
2.2465 0 Td
(and)Tj
1.8567 0 Td
(social)Tj
2.7284 0 Td
(plasticity)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
95.5276 34.9228 m
251.8299 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Genetics)Tj
4.1102 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4749 0 Td
(https://)Tj
2.9551 0 Td
(doi.org/10.13)Tj
5.7331 0 Td
(71/journal.p)Tj
5.1237 0 Td
(gen.100)Tj
3.5433 0 Td
(6840)Tj
0 g
3.1819 0 Td
(July)Tj
1.963 0 Td
(13,)Tj
1.5874 0 Td
(2017)Tj
33.6121 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(21)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
36 707.6409 m
60.2079 707.6409 l
h
f*
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F9 1 Tf
1 TL
-0.025 Tc
0 0 Td
(NIH.gov)Tj
0 g
(\).)Tj
3.7771 0 Td
(The)Tj
1.5875 0 Td
(funders)Tj
3.0472 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1623 0 Td
(role)Tj
1.6157 0 Td
(in)Tj
0.8858 0 Td
(study)Tj
2.2678 0 Td
(design,)Tj
-15.9308 -1.3748 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.7347 0 Td
(and)Tj
1.5945 0 Td
(analysis)Tj
2.9622 0 Td
(,)Tj
0.4464 0 Td
(decision)Tj
3.2883 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
-17.9151 -1.3748 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F8 1 Tf
-6.7606 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
BT
10.3394 -6.2504 Td
(exist.)Tj
ET
Q
endstream
endobj
49 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 51 0 R/Contents 52 0 R/TrimBox[0 0 612 792]>>
endobj
51 0 obj
[53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R]
endobj
53 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref021)>>
endobj
54 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref022)>>
endobj
55 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref023)>>
endobj
56 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref016)>>
endobj
57 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref017)>>
endobj
58 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.s003)>>
endobj
59 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.g001)>>
endobj
60 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.g001)>>
endobj
61 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.g001)>>
endobj
62 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.ref024)>>
endobj
63 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.g001)>>
endobj
64 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.s004)>>
endobj
65 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.g001)>>
endobj
66 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.s005)>>
endobj
67 0 obj
<>/Border[0 0 0]/Dest(Rpgen.1006840.g001)>>
endobj
68 0 obj
<>/Border[0 0 0]/A 69 0 R>>
endobj
69 0 obj
<>
endobj
52 0 obj
[70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R]
endobj
70 0 obj
<>stream
q
0.83 0.64 0.02 0 k
242.589 654.3496 m
252.0567 654.3496 l
h
f*
256.5354 654.3496 m
266.0598 654.3496 l
h
f*
499.2945 589.3228 m
508.8189 589.3228 l
h
f*
380.6362 459.326 m
390.1606 459.326 l
h
f*
394.5827 459.326 m
404.1071 459.326 l
h
f*
434.3811 341.915 m
468.2835 341.915 l
h
f*
522.0283 328.9323 m
548.4472 328.9323 l
h
f*
471.3449 302.9102 m
497.7638 302.9102 l
h
f*
258.5197 276.9449 m
314.7591 276.9449 l
h
f*
355.9748 224.9008 m
365.4992 224.9008 l
h
f*
461.3102 211.9181 m
488.0126 211.9181 l
h
f*
492.4913 211.9181 m
526.3937 211.9181 l
h
f*
319.9748 159.9307 m
376.8378 159.9307 l
h
f*
425.8205 120.926 m
459.7795 120.926 l
h
f*
504.8504 94.9039 m
529.6819 94.9039 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(defend)Tj
2.9593 0 Td
(a)Tj
0.652 0 Td
(territory,)Tj
3.8097 0 Td
(he)Tj
1.1679 0 Td
(will)Tj
1.6667 0 Td
(not)Tj
1.5761 0 Td
(obtain)Tj
2.7779 0 Td
(a)Tj
0.6577 0 Td
(mate)Tj
2.194 0 Td
(and)Tj
1.7291 0 Td
(he)Tj
1.1735 0 Td
(will)Tj
1.6611 0 Td
(not)Tj
1.5761 0 Td
(produce)Tj
3.5149 0 Td
(offspring)Tj
3.8324 0 Td
(therefore)Tj
3.8551 0 Td
(effec-)Tj
-34.8035 -1.3039 Td
(tive)Tj
1.661 0 Td
(defense)Tj
3.2145 0 Td
(of)Tj
1.0148 0 Td
(that)Tj
1.7802 0 Td
(territory)Tj
3.5829 0 Td
(is)Tj
0.8504 0 Td
(necessary)Tj
4.0195 0 Td
(for)Tj
1.389 0 Td
(reproductive)Tj
5.3291 0 Td
(success.)Tj
3.3278 0 Td
(Like)Tj
1.9446 0 Td
(other)Tj
2.3471 0 Td
(territorial)Tj
4.0762 0 Td
(ani-)Tj
-34.5371 -1.2982 Td
(mals,)Tj
2.3073 0 Td
(male)Tj
2.143 0 Td
(sticklebacks)Tj
4.9549 0 Td
(exhibit)Tj
2.9764 0 Td
(experience-dependent)Tj
9.0992 0 Td
(changes)Tj
3.4015 0 Td
(in)Tj
1.0375 0 Td
(behavior)Tj
3.7077 0 Td
(following)Tj
3.9798 0 Td
(a)Tj
-33.6073 -1.2983 Td
(territorial)Tj
4.0761 0 Td
(intrusion,)Tj
4.1386 0 Td
(as)Tj
1.0148 0 Td
(they)Tj
1.9275 0 Td
(learn)Tj
2.2394 0 Td
(the)Tj
1.474 0 Td
(boundaries)Tj
4.6942 0 Td
(of)Tj
1.0147 0 Td
(their)Tj
2.109 0 Td
(territory)Tj
3.583 0 Td
(and)Tj
1.7291 0 Td
(how)Tj
1.9389 0 Td
(to)Tj
1.0261 0 Td
(detect)Tj
2.6136 0 Td
(and)Tj
1.7291 0 Td
(repel)Tj
-35.3081 -1.2983 Td
(intruders)Tj
3.9174 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(22)Tj
0 g
(].)Tj
-4.456 -1.3039 Td
(We)Tj
1.61 0 Td
(provide)Tj
3.2882 0 Td
(evidence)Tj
3.7134 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4683 0 Td
(genome)Tj
3.4073 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(epigenome)Tj
4.6148 0 Td
(are)Tj
1.4456 0 Td
(highly)Tj
2.7099 0 Td
(responsive)Tj
4.4561 0 Td
(to)Tj
1.0261 0 Td
(social)Tj
-33.9191 -1.2982 Td
(interactions)Tj
4.9662 0 Td
(during)Tj
2.931 0 Td
(territory)Tj
3.583 0 Td
(defense.)Tj
3.4412 0 Td
(We)Tj
1.6044 0 Td
(characterize)Tj
5.0343 0 Td
(transcriptomic)Tj
6.1285 0 Td
(and)Tj
1.7291 0 Td
(epigenomic)Tj
4.8812 0 Td
(plastic-)Tj
-34.2989 -1.2983 Td
(ity)Tj
1.2415 0 Td
(in)Tj
1.0318 0 Td
(response)Tj
3.7361 0 Td
(to)Tj
1.0261 0 Td
(social)Tj
2.4548 0 Td
(interactions)Tj
4.9719 0 Td
(by)Tj
1.1792 0 Td
(measuring)Tj
4.4391 0 Td
(changes)Tj
3.4015 0 Td
(in)Tj
1.0375 0 Td
(gene)Tj
2.0806 0 Td
(expression)Tj
4.4617 0 Td
(at)Tj
0.9524 0 Td
(three)Tj
2.2677 0 Td
(points)Tj
-34.2819 -1.3039 Td
(in)Tj
1.0318 0 Td
(time)Tj
2.0295 0 Td
(following)Tj
3.9799 0 Td
(a)Tj
0.6576 0 Td
(brief)Tj
2.0749 0 Td
(territorial)Tj
4.0762 0 Td
(intrusion)Tj
3.9175 0 Td
(using)Tj
2.3868 0 Td
(RNA-Seq.)Tj
4.2462 0 Td
(We)Tj
1.6101 0 Td
(compare)Tj
3.7134 0 Td
(expression)Tj
4.4673 0 Td
(in)Tj
1.0318 0 Td
(two)Tj
-35.223 -1.2983 Td
(parts)Tj
2.1996 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(brain)Tj
2.3527 0 Td
(containing)Tj
4.5241 0 Td
(nodes)Tj
2.5908 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(social)Tj
2.4548 0 Td
(decision-making)Tj
6.9278 0 Td
(network)Tj
3.549 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(]:)Tj
2.0749 0 Td
(diencephalon)Tj
-31.6627 -1.2983 Td
(and)Tj
1.7291 0 Td
(telencephalon.)Tj
6.0151 0 Td
(The)Tj
1.7801 0 Td
(diencephalon)Tj
5.6126 0 Td
(includes)Tj
3.5489 0 Td
(the)Tj
1.4684 0 Td
(hypothalamusa)Tj
6.8257 0 Td
(key)Tj
1.5931 0 Td
(integrator)Tj
4.2066 0 Td
(of)Tj
1.0148 0 Td
(social)Tj
-33.7944 -1.3039 Td
(information)Tj
5.0739 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(neuroendocrine)Tj
6.6387 0 Td
(systemwhile)Tj
5.6012 0 Td
(the)Tj
1.474 0 Td
(telencephalon)Tj
5.7827 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.6519 0 Td
(part)Tj
1.8425 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(fore-)Tj
-33.8681 -1.2982 Td
(brain,)Tj
2.5738 0 Td
(and)Tj
1.7291 0 Td
(includes)Tj
3.5433 0 Td
(the)Tj
1.4683 0 Td
(teleost)Tj
2.778 0 Td
(homolog)Tj
3.804 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(hippocampus.)Tj
5.862 0 Td
(Using)Tj
2.6022 0 Td
(these)Tj
2.2507 0 Td
(data,)Tj
2.1429 0 Td
(we)Tj
1.3267 0 Td
(construct)Tj
3.9798 0 Td
(a)Tj
-36.544 -1.2983 Td
(transcriptional)Tj
6.1114 0 Td
(regulatory)Tj
4.32 0 Td
(network)Tj
3.5489 0 Td
(that)Tj
1.7802 0 Td
(links)Tj
2.1373 0 Td
(temporal)Tj
3.8381 0 Td
(changes)Tj
3.4015 0 Td
(in)Tj
1.0375 0 Td
(gene)Tj
2.0806 0 Td
(expression)Tj
4.4674 0 Td
(in)Tj
1.0318 0 Td
(different)Tj
-33.7547 -1.3039 Td
(parts)Tj
2.1996 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(brain)Tj
2.3527 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(activity)Tj
3.1181 0 Td
(of)Tj
1.0148 0 Td
(transcription)Tj
5.4311 0 Td
(factors)Tj
2.9027 0 Td
(operating)Tj
4.0535 0 Td
(within)Tj
2.8119 0 Td
(a)Tj
0.652 0 Td
(gene)Tj
2.0806 0 Td
(regulatory)Tj
4.32 0 Td
(net-)Tj
-35.9147 -1.2983 Td
(work.)Tj
2.4944 0 Td
(Finally,)Tj
3.1635 0 Td
(we)Tj
1.3209 0 Td
(measure)Tj
3.5773 0 Td
(changes)Tj
3.3959 0 Td
(in)Tj
1.0261 0 Td
(chromatin)Tj
4.4107 0 Td
(accessibility)Tj
4.9493 0 Td
(in)Tj
1.0261 0 Td
(response)Tj
3.7247 0 Td
(to)Tj
1.0205 0 Td
(a)Tj
0.6463 0 Td
(social)Tj
2.4491 0 Td
(interaction)Tj
-33.2048 -1.2982 Td
(on)Tj
1.2755 0 Td
(a)Tj
0.652 0 Td
(genome-wide)Tj
5.6636 0 Td
(scale,)Tj
2.33 0 Td
(using)Tj
2.3925 0 Td
(acetylated)Tj
4.1839 0 Td
(lysine)Tj
2.5171 0 Td
(27)Tj
1.1736 0 Td
(on)Tj
1.2756 0 Td
(histone)Tj
3.1521 0 Td
(H3)Tj
1.4626 0 Td
(\(H3K27Ac\))Tj
4.8756 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(marker)Tj
3.1351 0 Td
(of)Tj
-35.7616 -1.2983 Td
(accessible)Tj
4.0875 0 Td
(chromatin,)Tj
4.6431 0 Td
(and)Tj
1.7291 0 Td
(link)Tj
1.7802 0 Td
(changes)Tj
3.4015 0 Td
(in)Tj
1.0375 0 Td
(chromatin)Tj
4.4164 0 Td
(accessibility)Tj
4.9549 0 Td
(to)Tj
1.0261 0 Td
(changes)Tj
3.4016 0 Td
(in)Tj
1.0374 0 Td
(gene)Tj
2.0807 0 Td
(expres-)Tj
-33.596 -1.3039 Td
(sion.)Tj
2.1259 0 Td
(We)Tj
1.6101 0 Td
(show)Tj
2.3017 0 Td
(that)Tj
1.7745 0 Td
(many)Tj
2.4774 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4741 0 Td
(same)Tj
2.2563 0 Td
(principles)Tj
4.1612 0 Td
(that)Tj
1.7802 0 Td
(characterize)Tj
5.0286 0 Td
(transcriptomic)Tj
6.1285 0 Td
(and)Tj
1.7291 0 Td
(epige-)Tj
-33.8624 -1.2983 Td
(nomic)Tj
2.7836 0 Td
(changes)Tj
3.4015 0 Td
(unfolding)Tj
4.1499 0 Td
(over)Tj
1.9729 0 Td
(development)Tj
5.4141 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(17)Tj
0 g
(])Tj
1.5137 0 Td
(also)Tj
1.7688 0 Td
(apply)Tj
2.3868 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(brain's)Tj
2.9253 0 Td
(response)Tj
3.7304 0 Td
(to)Tj
1.0261 0 Td
(brief,)Tj
-35.3024 -1.2983 Td
(but)Tj
1.5533 0 Td
(potent,)Tj
3.0387 0 Td
(social)Tj
2.4548 0 Td
(behavior.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 405.0141 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
/F0 1 Tf
0 -1.5023 Td
(Spatiotemporal)Tj
6.8646 0 Td
(dynamics)Tj
4.3984 0 Td
(of)Tj
1.0441 0 Td
(the)Tj
1.5969 0 Td
(transcriptomic)Tj
6.3733 0 Td
(response)Tj
4.285 0 Td
(to)Tj
1.0442 0 Td
(territorial)Tj
-25.6065 -1.167 Td
(challenge)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 355.9748 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Within)Tj
3.0954 0 Td
(both)Tj
2.0579 0 Td
(brain)Tj
2.3471 0 Td
(regions,)Tj
3.3902 0 Td
(we)Tj
1.3266 0 Td
(identified)Tj
4.0592 0 Td
(genes)Tj
2.4434 0 Td
(whose)Tj
2.7213 0 Td
(expression)Tj
4.4673 0 Td
(was)Tj
1.6952 0 Td
(influenced)Tj
4.4447 0 Td
(by)Tj
1.1848 0 Td
(a)Tj
0.652 0 Td
(territo-)Tj
-33.8851 -1.2982 Td
(rial)Tj
1.5363 0 Td
(challenge)Tj
3.9572 0 Td
(at)Tj
0.9524 0 Td
(three)Tj
2.2677 0 Td
(time)Tj
2.0296 0 Td
(points:)Tj
2.9423 0 Td
(30,)Tj
1.3947 0 Td
(60)Tj
1.1735 0 Td
(and)Tj
1.7291 0 Td
(120)Tj
1.6498 0 Td
(minutes)Tj
3.4639 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1)Tj
1.5137 0 Td
(Table)Tj
0 g
(\).)Tj
3.0047 0 Td
(The)Tj
1.7801 0 Td
(greatest)Tj
3.2995 0 Td
(transcrip-)Tj
-32.6945 -1.2983 Td
(tional)Tj
2.5171 0 Td
(response)Tj
3.736 0 Td
(to)Tj
1.0262 0 Td
(a)Tj
0.6519 0 Td
(territorial)Tj
4.0762 0 Td
(challenge)Tj
3.9572 0 Td
(occurred)Tj
3.7984 0 Td
(60)Tj
1.1678 0 Td
(minutes)Tj
3.4696 0 Td
(after)Tj
2.0353 0 Td
(the)Tj
1.4683 0 Td
(challenge)Tj
3.9572 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1A)Tj
0 g
(\).)Tj
-33.681 -1.2982 Td
(Generally,)Tj
4.3086 0 Td
(gene)Tj
2.0806 0 Td
(expression)Tj
4.4617 0 Td
(was)Tj
1.7008 0 Td
(down-regulated)Tj
6.5593 0 Td
(30)Tj
1.1679 0 Td
(and)Tj
1.7291 0 Td
(60)Tj
1.1735 0 Td
(minutes)Tj
3.464 0 Td
(after)Tj
2.0352 0 Td
(the)Tj
1.4684 0 Td
(social)Tj
2.4604 0 Td
(challenge)Tj
-32.6095 -1.304 Td
(but)Tj
1.5533 0 Td
(was)Tj
1.6951 0 Td
(up-regulated)Tj
5.3348 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(120)Tj
1.6497 0 Td
(minute)Tj
3.1011 0 Td
(time)Tj
2.0296 0 Td
(point)Tj
2.3584 0 Td
(in)Tj
1.0375 0 Td
(diencephalon)Tj
5.6126 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1A)Tj
0 g
(\).)Tj
-27.4165 -1.2982 Td
(The)Tj
1.7858 0 Td
(transcriptomic)Tj
6.1284 0 Td
(response)Tj
3.7304 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(territorial)Tj
4.0762 0 Td
(challenge)Tj
3.9628 0 Td
(changed)Tj
3.566 0 Td
(rapidly)Tj
3.0387 0 Td
(over)Tj
1.9786 0 Td
(time)Tj
2.0296 0 Td
(in)Tj
1.0318 0 Td
(both)Tj
-34.2026 -1.2983 Td
(brain)Tj
2.347 0 Td
(regions)Tj
3.1635 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1B)Tj
1.2756 0 Td
(and)Tj
1.7291 0 Td
(1C)Tj
0 g
(\);)Tj
1.9275 0 Td
(in)Tj
1.0319 0 Td
(fact,)Tj
1.8935 0 Td
(there)Tj
2.262 0 Td
(was)Tj
1.7008 0 Td
(little)Tj
1.9956 0 Td
(overlap)Tj
3.1748 0 Td
(between)Tj
3.5319 0 Td
(the)Tj
1.4683 0 Td
(differentially)Tj
-29.3213 -1.3039 Td
(expressed)Tj
4.0932 0 Td
(genes)Tj
2.4434 0 Td
(detected)Tj
3.566 0 Td
(at)Tj
0.9524 0 Td
(each)Tj
2.0239 0 Td
(time)Tj
2.0296 0 Td
(point.)Tj
2.5852 0 Td
(Functional)Tj
4.5467 0 Td
(enrichment)Tj
4.8756 0 Td
(analysis)Tj
3.3222 0 Td
(revealed)Tj
3.5263 0 Td
(that)Tj
-33.9645 -1.2983 Td
(early)Tj
2.1486 0 Td
(responding)Tj
4.7565 0 Td
(genes)Tj
2.4435 0 Td
(\(30)Tj
1.508 0 Td
(minutes\))Tj
3.8097 0 Td
(were)Tj
2.1203 0 Td
(related)Tj
2.948 0 Td
(to)Tj
1.0205 0 Td
(hormones)Tj
4.286 0 Td
(and)Tj
1.7347 0 Td
(post-translational)Tj
7.2454 0 Td
(modifi-)Tj
-34.0212 -1.2982 Td
(cations)Tj
3.0557 0 Td
(\(PTMs\),)Tj
3.5489 0 Td
(whereas)Tj
3.4469 0 Td
(a)Tj
0.652 0 Td
(strong)Tj
2.7723 0 Td
(signature)Tj
3.9174 0 Td
(of)Tj
1.0148 0 Td
(genes)Tj
2.4435 0 Td
(related)Tj
2.9423 0 Td
(to)Tj
1.0262 0 Td
(metabolism)Tj
4.9039 0 Td
(dominated)Tj
4.575 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
-35.2514 -1.304 Td
(60)Tj
1.1678 0 Td
(minute)Tj
3.1068 0 Td
(time)Tj
2.0296 0 Td
(point)Tj
2.3584 0 Td
(\(consistent)Tj
4.5977 0 Td
(with)Tj
1.9956 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(]\).)Tj
2.4151 0 Td
(By)Tj
1.2586 0 Td
(120)Tj
1.6441 0 Td
(minutes,)Tj
3.6907 0 Td
(differentially)Tj
5.3064 0 Td
(expressed)Tj
4.0932 0 Td
(functions)Tj
-33.664 -1.2982 Td
(shifted)Tj
2.9139 0 Td
(toward)Tj
3.0388 0 Td
(transcription,)Tj
5.6579 0 Td
(immune)Tj
3.6283 0 Td
(response)Tj
3.736 0 Td
(and)Tj
1.7292 0 Td
(homeostasis)Tj
5.0853 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1G)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.6384 0 Td
(S2)Tj
1.1679 0 Td
(Table)Tj
0 g
(\).)Tj
-29.2193 -1.2983 Td
(Not)Tj
1.7631 0 Td
(surprisingly,)Tj
5.2044 0 Td
(we)Tj
1.3266 0 Td
(detected)Tj
3.5659 0 Td
(strong)Tj
2.7723 0 Td
(differences)Tj
4.5638 0 Td
(in)Tj
1.0374 0 Td
(gene)Tj
2.0807 0 Td
(expression)Tj
4.4673 0 Td
(between)Tj
3.5263 0 Td
(brain)Tj
2.3471 0 Td
(regions.)Tj
-33.8511 -1.3039 Td
(However,)Tj
4.0761 0 Td
(there)Tj
2.2621 0 Td
(were)Tj
2.1259 0 Td
(some)Tj
2.3301 0 Td
(genes)Tj
2.4435 0 Td
(that)Tj
1.7744 0 Td
(were)Tj
2.126 0 Td
(differentially)Tj
5.3008 0 Td
(expressed)Tj
4.0932 0 Td
(in)Tj
1.0374 0 Td
(both)Tj
2.058 0 Td
(brain)Tj
2.3527 0 Td
(regions,)Tj
3.3846 0 Td
(and)Tj
-35.3648 -1.2983 Td
(these)Tj
2.2506 0 Td
(genes)Tj
2.4435 0 Td
(showed)Tj
3.2485 0 Td
(a)Tj
0.6576 0 Td
(remarkably)Tj
4.7792 0 Td
(concordant)Tj
4.8075 0 Td
(quantitative)Tj
4.9776 0 Td
(pattern)Tj
3.1124 0 Td
(of)Tj
1.0148 0 Td
(expression)Tj
4.4674 0 Td
(across)Tj
2.6759 0 Td
(brain)Tj
-34.435 -1.2982 Td
(regions)Tj
3.1634 0 Td
(at)Tj
0.9524 0 Td
(30)Tj
1.1679 0 Td
(and)Tj
1.7348 0 Td
(60)Tj
1.1679 0 Td
(minutes)Tj
3.4695 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8199 0 Td
(1D)Tj
1.4286 0 Td
(and)Tj
1.7291 0 Td
(1E)Tj
0 g
(\).)Tj
1.8312 0 Td
(Specifically,)Tj
4.9153 0 Td
(genes)Tj
2.4377 0 Td
(that)Tj
1.7802 0 Td
(were)Tj
2.1203 0 Td
(strongly)Tj
3.4752 0 Td
(upregu-)Tj
-33.1934 -1.2983 Td
(lated)Tj
2.1486 0 Td
(in)Tj
1.0375 0 Td
(diencephalon)Tj
5.6125 0 Td
(in)Tj
1.0375 0 Td
(response)Tj
3.7304 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(territorial)Tj
4.0762 0 Td
(challenge)Tj
3.9571 0 Td
(were)Tj
2.126 0 Td
(also)Tj
1.7688 0 Td
(strongly)Tj
3.4696 0 Td
(upregulated)Tj
4.9833 0 Td
(in)Tj
-35.6256 -1.3039 Td
(telencephalon)Tj
5.7883 0 Td
(\(correlation)Tj
/F12 1 Tf
0 Tc
4.9549 0 Td
(>)Tj
/F7 1 Tf
-0.004 Tc
0.9921 0 Td
(0.9\).)Tj
1.9616 0 Td
(The)Tj
1.7858 0 Td
(pattern)Tj
3.1067 0 Td
(at)Tj
0.9525 0 Td
(120)Tj
1.6497 0 Td
(minutes)Tj
3.4639 0 Td
(was)Tj
1.7008 0 Td
(different,)Tj
3.8835 0 Td
(with)Tj
1.9955 0 Td
(a)Tj
0.652 0 Td
(subset)Tj
2.6986 0 Td
(of)Tj
-35.5859 -1.2983 Td
(genes)Tj
2.4377 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7994 0 Td
(18,)Tj
1.3946 0 Td
(hereafter)Tj
3.7814 0 Td
(referred)Tj
3.4242 0 Td
(to)Tj
1.0262 0 Td
(as)Tj
1.0148 0 Td
(`discordant)Tj
4.7111 0 Td
(genes',)Tj
0.83 0.64 0.02 0 k
2.88 0 Td
(S3)Tj
1.1735 0 Td
(Table)Tj
0 g
(\))Tj
2.778 0 Td
(showing)Tj
3.5829 0 Td
(the)Tj
1.4684 0 Td
(opposite)Tj
3.617 0 Td
(pat-)Tj
-35.2004 -1.2982 Td
(tern)Tj
1.8595 0 Td
(of)Tj
1.0148 0 Td
(regulation)Tj
4.3086 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(two)Tj
1.7121 0 Td
(brain)Tj
2.3471 0 Td
(regions.)Tj
3.3902 0 Td
(These)Tj
2.5625 0 Td
(18)Tj
1.1735 0 Td
(genes,)Tj
2.6646 0 Td
(which)Tj
2.6532 0 Td
(were)Tj
2.1203 0 Td
(upregulated)Tj
4.9833 0 Td
(in)Tj
1.0375 0 Td
(dien-)Tj
-34.333 -1.304 Td
(cephalon)Tj
3.8437 0 Td
(and)Tj
1.7348 0 Td
(downregulated)Tj
6.2022 0 Td
(in)Tj
1.0374 0 Td
(telencephalon)Tj
5.7883 0 Td
(after)Tj
2.0353 0 Td
(the)Tj
1.4683 0 Td
(territorial)Tj
4.0762 0 Td
(challenge)Tj
3.9572 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1F)Tj
0 g
(\),)Tj
1.7915 0 Td
(are)Tj
-33.7547 -1.2982 Td
(primarily)Tj
3.9684 0 Td
(related)Tj
2.9424 0 Td
(to)Tj
1.0261 0 Td
(visual)Tj
2.5115 0 Td
(perception)Tj
4.5184 0 Td
(and)Tj
1.7291 0 Td
(include)Tj
3.1861 0 Td
(retinal)Tj
2.8063 0 Td
(genes)Tj
2.4435 0 Td
(\(e.g.)Tj
/F11 1 Tf
1.8992 0 Td
[()20()11(\r)]TJ
/F7 1 Tf
(,)Tj
/F11 1 Tf
2.9877 0 Td
[()20()11()]TJ
1.8255 0 Td
[()]TJ
/F7 1 Tf
(,)Tj
1.3946 0 Td
(opsins\),)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 133.6819 23.6976 re
W* n
q
133.6252 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 452.4094 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Neurogeno)Tj
4.8543 0 Td
(mics)Tj
2.2465 0 Td
(and)Tj
1.8567 0 Td
(social)Tj
2.7284 0 Td
(plasticity)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
95.5276 34.9228 m
251.8299 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(Genetics)Tj
4.1102 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4749 0 Td
(https://)Tj
2.9551 0 Td
(doi.org/10.13)Tj
5.7331 0 Td
(71/journal.p)Tj
5.1237 0 Td
(gen.100)Tj
3.5433 0 Td
(6840)Tj
0 g
3.1819 0 Td
(July)Tj
1.963 0 Td
(13,)Tj
1.5874 0 Td
(2017)Tj
33.6121 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
endstream
endobj
74 0 obj
<>stream
endstream
endobj
75 0 obj
<>stream
endstream
endobj
76 0 obj
<>stream
endstream
endobj
77 0 obj
<>stream
endstream
endobj
78 0 obj
<>stream
endstream
endobj
79 0 obj
<>stream
endstream
endobj
80 0 obj
<>stream
endstream
endobj
81 0 obj
<>stream
endstream
endobj
82 0 obj
<>stream
BT
66.402 0 Td
(21)Tj
ET
Q
endstream
endobj
83 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 85 0 R/Contents 86 0 R/TrimBox[0 0 612 792]>>
endobj
84 0 obj
<>stream
x]|NH{/!PBQAT,4#
RP@W)TTH){$wgwr@~μ3L}B B B B B B B B B B B B B(sdeep̍D !@ !@#G:=)9 !PZmjjj``/QQ3#